The common chemotherapeutic regimens, which include platinum analogs, doxorubicin, taxanes, and camptothecin (CPT) analogs, are recommended for treating endometrial cancer patients. The prognosis for such cases is poor, with a survival rate of approximately 20%.
Radiotherapy and chemotherapy are the primary treatment approaches for advanced and recurrent endometrial cancer. IntroductionĮndometrial cancer is a highly prevalent gynecological malignancy worldwide. These results indicated that AE-CA is a potent antitumor agent and can be combined with cisplatin for the treatment of human endometrial cancer. Furthermore, AE-CA exhibited a synergistic effect on the cytotoxicity of cisplatin in HEC-1A and HEC-1B cells. The effects of AE-CA on the induction of cell cycle arrest, the accumulation of cyclin-A2 and -B1, and the activation of caspase-3 and caspase-7 were similar to those of CPT. Cell viability assays indicated that a dosage of AE-CA containing 0.28 mg/mL of CPT demonstrated enhanced cytotoxicity, compared with CPT treatment. acuminata (AE-CA) in the human endometrial carcinoma cell lines, HEC-1A, HEC-1B, and KLE, and compare its antitumor effects with those of CPT. The aims of our current study were to determine the tumor-suppression efficiency of an aqueous extract of the fruit of C. Although the antitumor effects of CPT have been characterized in recent years, the antitumor effects of aqueous extracts of C. The chemotherapeutic drug, camptothecin (CPT), and related analogs were first isolated from C. The aqueous extracts of the leaves and fruit of Camptotheca acuminata have long been used in traditional Chinese medicine (TCM) for treating cancer patients.
1 Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, TaiwanĢ Department of Surgery, Chi Mei Hospital Chiali, Tainan 170, Taiwanģ Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanĤ Division of Hematology and Oncology, Department of Internal Medicine, Taipei Medical University Hospital, 252 Wu Hsing Street, Taipei 110, Taiwanĥ Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanĦ Department of Chinese Medicine, Taipei Medical University Hospital, 252 Wu Hsing Street, Taipei 110, Taiwanħ Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei 110, TaiwanĨ Cancer Research Center, Taipei Medical University and Hospital, Taipei 110, Taiwanĩ Department of Surgery, Taipei Medical University and Hospital, Taipei 110, Taiwanġ0 Division of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei 110, Taiwanġ1 Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwanġ2 Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan Show more